Professor
Ben Seymour
BSc MB ChB PhD MRCP FRSA
Wellcome Senior Clinical Fellow
Professor of Clinical Neuroscience
Research
Impact
Tonic pain modulates neural correlates of associative phasic pain memories.
Hewitt D,  Tong S,  Schreiber S,  Seymour B,  et al. (2026)
Why sleep matters in chronic pain: evidence across the lifespan
Kelleher EM,  Wall A,  Seymour B,  Irani A,  et al. (2026)
Serum Neurofilament Light Chain in Fibromyalgia: Comparative Evidence of Neuronal Injury Across Chronic Pain Conditions.
Fundaun J,  Kelleher E,  Coxon L,  Wall A,  John J,  Garbutt K,  Themistocleous AC,  Terajima Y,  Bennett DL,  Vincent K,  Irani A,  Schmid A,  et al. (2026)
Short-term variability of chronic musculoskeletal pain
Zheng X,  Rajwal S,  Ashworth C,  Ho SYS,  Seymour B,  Shenker N,  Mancini F,  et al. (2025)
Balancing safety and efficiency in human decision making
Mahajan P,  Tong S,  Lee SW,  Seymour B,  et al. (2025)
Brain signatures of nociplastic pain: Fibromyalgia Index and descending modulation at population level.
Kelleher EM,  Lange F,  Wanigasekera V,  Rathod-Mistry T,  Nichols T,  Seymour B,  Tracey I,  Segerdahl AR,  Irani A,  et al. (2025)
Characterization of CNS Network Changes in Two Rodent Models of Chronic Pain
Sprenger C,  Kanbara T,  Yamada T,  Morikawa Y,  Koda K,  Kashiwagi Y,  Mano H,  Morioka Y,  Seymour B,  et al. (2025)
Short-term variability of chronic musculoskeletal pain
Zheng X,  Rajwal S,  Ashworth C,  Ho SYS,  Seymour B,  Shenker N,  Mancini F,  et al. (2025)
The AI4Pain Grand Challenge 2025: Advancing Pain Assessment with Multimodal Physiological Signals
Fernandez-Rojas R,  Joseph C,  Hirachan N,  Seymour B,  Goecke R,  et al. (2025)
Wirelessly transmitted subthalamic nucleus signals decode endogenous pain levels in Parkinson's disease patients
Reza A,  Yanagisawa T,  Tani N,  Fukuma R,  Emura T,  Oshino S,  Seymour B,  Kishima H,  et al. (2025)
Phasic and tonic pain serve distinct functions during adaptive behaviour
Tong S,  Denison T,  Hewitt D,  Lee SW,  Seymour B,  et al. (2025)
Phasic and tonic pain serve distinct functions during adaptive behaviour
Tong S,  Denison T,  Hewitt D,  Lee SW,  Seymour B,  et al. (2025)
Balancing safety and efficiency in human decision making
Mahajan P,  Tong S,  Lee SW,  Seymour B,  et al. (2024)
Enhanced behavioural and neural sensitivity to punishments in chronic pain and fatigue
Mancini F,  Mahajan P,  Guttesen A,  Onysk J,  Scholtes I,  Shenker N,  Lee M,  Seymour B,  et al. (2024)
Neurofeedback modulation of insula activity via MEG-based brain-machine interface: A double-blind randomized controlled crossover trial
Yanagisawa T,  Wang Y,  Fukuma R,  Seymour B,  Yang H,  Kishima H,  et al. (2024)
Statistical learning shapes pain perception and prediction independently of external cues.
Onysk J,  Gregory N,  Whitefield M,  Jain M,  Turner G,  Seymour B,  Mancini F,  et al. (2024)
Balancing safety and efficiency in human decision making
Mahajan P,  Tong S,  Lee SW,  Seymour B,  et al. (2024)
Balancing safety and efficiency in human decision making
Mahajan P,  Tong S,  Lee SW,  Seymour B,  et al. (2024)
How the magnitude and precision of pain predictions shape pain experiences.
Derksen SMJC,  Konttinen M,  Myronenko A,  Seymour B,  Peerdeman KJ,  et al. (2024)
Enhanced behavioural and neural sensitivity to punishments in chronic pain and fatigue.
Mancini F,  Mahajan P,  Guttesen AÁV,  Onysk J,  Scholtes I,  Shenker N,  Lee M,  Seymour B,  et al. (2024)
The AI4Pain Grand Challenge 2024: Advancing Pain Assessment with Multimodal fNIRS and Facial Video Analysis
Fernandez–Rojas R,  Joseph C,  Hirachan N,  Seymour B,  Goecke R,  et al. (2024)
Automated Assessment of Pain (AAP) and Multimodal Sensing Grand Challenge for Next-Gen Pain Assessment (AI4Pain)
Hammal Z,  Walter S,  Berthouze N,  Fernandez-Rojas R,  Seymour B,  Goecke R,  et al. (2024)
Evidence for dopaminergic involvement in endogenous modulation of pain relief.
Desch S,  Schweinhardt P,  Seymour B,  Flor H,  Becker S,  et al. (2023)
Confidence of probabilistic predictions modulates the cortical response to pain.
Mulders D,  Seymour B,  Mouraux A,  Mancini F,  et al. (2023)
Improving sleep and learning in rehabilitation after stroke, part 2 (INSPIRES2): study protocol for a home-based randomised control trial of digital cognitive behavioural therapy (dCBT) for insomnia
Weightman M,  Robinson B,  Fallows R,  Henry AL,  Kyle SD,  Garratt E,  Pick A,  Teal R,  Ajina S,  Demeyere N,  Espie CA,  Seymour B,  Johansen-Berg H,  Fleming MK,  et al. (2023)
Post-injury pain and behaviour: a control theory perspective.
Seymour B,  Crook RJ,  Chen ZS,  et al. (2023)
Multimodal physiological sensing for the assessment of acute pain.
Fernandez Rojas R,  Hirachan N,  Brown N,  Waddington G,  Murtagh L,  Seymour B,  Goecke R,  et al. (2023)
Statistical learning shapes pain perception and prediction independently of external cues
Onysk J,  Gregory N,  Whitefield M,  Jain M,  Turner G,  Seymour B,  Mancini F,  et al. (2023)
Neurofeedback Training without Explicit Phantom Hand Movements and Hand-Like Visual Feedback to Modulate Pain: A Randomized Crossover Feasibility Trial.
Yanagisawa T,  Fukuma R,  Seymour B,  Tanaka M,  Yamashita O,  Hosomi K,  Kishima H,  Kamitani Y,  Saitoh Y,  et al. (2022)
Confidence of probabilistic predictions modulates the cortical response to pain
Mulders D,  Seymour B,  Mouraux A,  Mancini F,  et al. (2022)
Endogenous modulation of pain relief: evidence for dopaminergic but not opioidergic involvement
Desch S,  Schweinhardt P,  Seymour B,  Flor H,  Becker S,  et al. (2022)
Computational and neural mechanisms of statistical pain learning.
Mancini F,  Zhang S,  Seymour B,  et al. (2022)
A multi-site, multi-disorder resting-state magnetic resonance image database
Tanaka SC,  Yamashita A,  Yahata N,  Yoshida W,  Seymour B,  et al. (2021)
Learning the statistics of pain: computational and neural mechanisms
Mancini F,  Zhang S,  Seymour B,  et al. (2021)
Learning the statistics of pain: computational and neural mechanisms
Mancini F,  Zhang S,  Seymour B,  et al. (2021)
BCI training to move a virtual hand reduces phantom limb pain: A randomized crossover trial.
Yanagisawa T,  Fukuma R,  Seymour B,  Tanaka M,  Hosomi K,  Yamashita O,  Kishima H,  Kamitani Y,  Saitoh Y,  et al. (2020)
An Evolutionarily Threat-Relevant Odor Strengthens Human Fear Memory.
Taylor JE,  Lau H,  Seymour B,  Nakae A,  Sumioka H,  Kawato M,  Koizumi A,  et al. (2020)
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants.
Ichikawa N,  Lisi G,  Yahata N,  Okada G,  Takamura M,  Hashimoto R-I,  Yamada T,  Yamada M,  Suhara T,  Moriguchi S,  Mimura M,  Yoshihara Y,  Takahashi H,  Kasai K,  Kato N,  Yamawaki S,  Seymour B,  Kawato M,  Morimoto J,  Okamoto Y,  et al. (2020)
Endogenous controllability of closed-loop brain-machine interfaces for pain
Zhang S,  Yoshida W,  Mano H,  Yanagisawa T,  Shibata K,  Kawato M,  Seymour B,  et al. (2020)
Pain Control by Co-adaptive Learning in a Brain-Machine Interface.
Zhang S,  Yoshida W,  Mano H,  Yanagisawa T,  Mancini F,  Shibata K,  Kawato M,  Seymour B,  et al. (2020)
Reward Enhances Pain Discrimination in Humans.
Becker S,  Löffler M,  Seymour B,  et al. (2020)
Publisher Correction: Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants.
Ichikawa N,  Lisi G,  Yahata N,  Okada G,  Takamura M,  Hashimoto R-I,  Yamada T,  Yamada M,  Suhara T,  Moriguchi S,  Mimura M,  Yoshihara Y,  Takahashi H,  Kasai K,  Kato N,  Yamawaki S,  Seymour B,  Kawato M,  Morimoto J,  Okamoto Y,  et al. (2020)
Towards prognostic functional brain biomarkers for cervical myelopathy: A resting-state fMRI study.
Takenaka S,  Kan S,  Seymour B,  Makino T,  Sakai Y,  Kushioka J,  Tanaka H,  Watanabe Y,  Shibata M,  Yoshikawa H,  Kaito T,  et al. (2019)
Editorial overview: Pain and aversive motivation
Johansen JP,  Seymour B,  et al. (2019)
The control of tonic pain by active relief learning.
Zhang S,  Mano H,  Lee M,  Yoshida W,  Kawato M,  Robbins TW,  Seymour B,  et al. (2018)
Value generalization in human avoidance learning.
Norbury A,  Robbins TW,  Seymour B,  et al. (2018)
A prediction model of working memory across health and psychiatric disease using whole-brain functional connectivity.
Yamashita M,  Yoshihara Y,  Hashimoto R,  Yahata N,  Ichikawa N,  Sakai Y,  Yamada T,  Matsukawa N,  Okada G,  Tanaka SC,  Kasai K,  Kato N,  Okamoto Y,  Seymour B,  Takahashi H,  Kawato M,  Imamizu H,  et al. (2018)
Classification and characterisation of brain network changes in chronic back pain: A multicenter study.
Mano H,  Kotecha G,  Leibnitz K,  Matsubara T,  Sprenger C,  Nakae A,  Shenker N,  Shibata M,  Voon V,  Yoshida W,  Lee M,  Yanagida T,  Kawato M,  Rosa MJ,  Seymour B,  et al. (2018)
MEG-BMI to Control Phantom Limb Pain.
Yanagisawa T,  Fukuma R,  Seymour B,  Hosomi K,  Kishima H,  Shimizu T,  Yokoi H,  Hirata M,  Yoshimine T,  Kamitani Y,  Saitoh Y,  et al. (2018)
Classification and characterisation of brain network changes in chronic back pain: A multicenter study
Mano H,  Kotecha G,  Leibnitz K,  Matsubara T,  Nakae A,  Shenker N,  Shibata M,  Voon V,  Yoshida W,  Lee M,  Yanagida T,  Kawato M,  Rosa MJ,  Seymour B,  et al. (2018)
Anterior cingulate cortex connectivity is associated with suppression of behavior in a rat model of chronic pain
Morris L,  Sprenger C,  Koda K,  de la Mora D,  Yamada T,  Mano H,  Kashiwagi Y,  Yoshioka Y,  Morioka Y,  Seymour B,  et al. (2017)
The control of tonic pain by active relief learning
Zhang S,  Mano H,  Lee M,  Yoshida W,  Kawato M,  Robbins T,  Seymour B,  et al. (2017)
Thermosensory Perceptual Learning Is Associated with Structural Brain Changes in Parietal-Opercular (SII) Cortex.
Mano H,  Yoshida W,  Shibata K,  Zhang S,  Koltzenburg M,  Kawato M,  Seymour B,  et al. (2017)
Disrupted habenula function in major depression.
Lawson RP,  Nord CL,  Seymour B,  Thomas DL,  Dayan P,  Pilling S,  Roiser JP,  et al. (2017)
Pain and Self-Preservation in Autonomous Robots: From Neurobiological Models to Psychiatric Disease
Piccolo L,  Liberal FD,  Bonarini A,  Scymour B,  Ishiguro H,  et al. (2017)
Fear reduction without fear through reinforcement of neural activity that bypasses conscious exposure.
Koizumi A,  Amano K,  Cortese A,  Shibata K,  Yoshida W,  Seymour B,  Kawato M,  Lau H,  et al. (2016)
Induced sensorimotor brain plasticity controls pain in phantom limb patients.
Yanagisawa T,  Fukuma R,  Seymour B,  Hosomi K,  Kishima H,  Shimizu T,  Yokoi H,  Hirata M,  Yoshimine T,  Kamitani Y,  Saitoh Y,  et al. (2016)
Deep brain stimulation of the subthalamic nucleus modulates sensitivity to decision outcome value in Parkinson's disease.
Seymour B,  Barbe M,  Dayan P,  Shiner T,  Dolan R,  Fink GR,  et al. (2016)
Dissociable Learning Processes Underlie Human Pain Conditioning.
Zhang S,  Mano H,  Ganesh G,  Robbins T,  Seymour B,  et al. (2016)
Distinct Contributions of Ventromedial and Dorsolateral Subregions of the Human Substantia Nigra to Appetitive and Aversive Learning.
Pauli WM,  Larsen T,  Collette S,  Tyszka JM,  Seymour B,  O'Doherty JP,  et al. (2015)
Accounting for Behavior in Treatment Effects: New Applications for Blind Trials.
Chassang S,  Snowberg E,  Seymour B,  Bowles C,  et al. (2015)
Modulating the pain network--neurostimulation for central poststroke pain.
Hosomi K,  Seymour B,  Saitoh Y,  et al. (2015)
Anticipation and choice heuristics in the dynamic consumption of pain relief.
Story GW,  Vlaev I,  Dayan P,  Seymour B,  Darzi A,  Dolan RJ,  et al. (2015)
Pain: a distributed brain information network?
Mano H,  Seymour B,  et al. (2015)
Prices need no preferences: social trends determine decisions in experimental markets for pain relief.
Vlaev I,  Seymour B,  Chater N,  Winston JS,  Yoshida W,  Wright N,  Symmonds M,  Dolan R,  et al. (2014)
The habenula encodes negative motivational value associated with primary punishment in humans.
Lawson RP,  Seymour B,  Loh E,  Lutti A,  Dolan RJ,  Dayan P,  Weiskopf N,  Roiser JP,  et al. (2014)
Technology for chronic pain.
Zhang S,  Seymour B,  et al. (2014)
Decisions about decisions.
Yoshida W,  Seymour B,  et al. (2014)
Decoding Acute Pain with Combined EEG and Physiological Data
Lancaster J,  Mano H,  Callan D,  Kawato M,  Seymour B,  et al. (2014)
Punishment-based decision making.
Dreher J-C,  Seymour B,  Tobler PN,  et al. (2014)
State-dependent value representation: evidence from the striatum.
Burke CJ,  Dreher J-C,  Seymour B,  Tobler PN,  et al. (2014)
The price of pain and the value of suffering.
Vlaev I,  Seymour B,  Dolan RJ,  Chater N,  et al. (2013)
Relative valuation of pain in human orbitofrontal cortex.
Winston JS,  Vlaev I,  Seymour B,  Chater N,  Dolan RJ,  et al. (2013)
The neural signature of escalating frustration in humans.
Yu R,  Mobbs D,  Seymour B,  Rowe JB,  Calder AJ,  et al. (2013)
Converging evidence for central 5-HT effects in acute tryptophan depletion.
Crockett MJ,  Clark L,  Roiser JP,  Robinson OJ,  Cools R,  Chase HW,  Ouden HD,  Apergis-Schoute A,  Campbell-Meiklejohn D,  Seymour B,  Sahakian BJ,  Rogers RD,  Robbins TW,  et al. (2012)
The effect of motivation on movement: a study of bradykinesia in Parkinson's disease
Shiner T,  Seymour B,  Symmonds M,  Dayan P,  Bhatia KP,  Dolan RJ,  et al. (2012)
Serotonin selectively modulates reward value in human decision-making.
Seymour B,  Daw ND,  Roiser JP,  Dayan P,  Dolan R,  et al. (2012)
Dopamine and performance in a reinforcement learning task: evidence from Parkinson's disease.
Shiner T,  Seymour B,  Wunderlich K,  Hill C,  Bhatia KP,  Dayan P,  Dolan RJ,  et al. (2012)
Erratum: Converging evidence for central 5-HT effects in acute tryptophan depletion
Crockett MJ,  Clark L,  Roiser JP,  Robinson OJ,  Cools R,  Chase HW,  den Ouden H,  Apergis-Schoute A,  Campbell-Meiklejohn D,  Seymour B,  Sahakian BJ,  Rogers RD,  Robbins TW,  et al. (2012)
Altruistic Learning
Seymour B,  Yoshida W,  Dolan R,  et al. (2012)
The Effect of Motivation on Movement: A Study of Bradykinesia in Parkinson's Disease
Shiner T,  Seymour B,  Symmonds M,  Dayan P,  Bhatia K,  Dolan R,  et al. (2011)
Model-based influences on humans' choices and striatal prediction errors.
Daw ND,  Gershman SJ,  Seymour B,  Dayan P,  Dolan RJ,  et al. (2011)
Pain relativity in motor control.
Kurniawan IT,  Seymour B,  Vlaev I,  Trommershäuser J,  Dolan RJ,  Chater N,  et al. (2010)
Insula and striatum mediate the default bias.
Yu R,  Mobbs D,  Seymour B,  Calder AJ,  et al. (2010)
Differentiable neural substrates for learned and described value and risk.
Fitzgerald THB,  Seymour B,  Bach DR,  Dolan RJ,  et al. (2010)
Neural mechanisms of belief inference during cooperative games.
Yoshida W,  Seymour B,  Friston KJ,  Dolan RJ,  et al. (2010)
Dopamine, time, and impulsivity in humans.
Pine A,  Shiner T,  Seymour B,  Dolan RJ,  et al. (2010)
Choosing to make an effort: the role of striatum in signaling physical effort of a chosen action.
Kurniawan IT,  Seymour B,  Talmi D,  Yoshida W,  Chater N,  Dolan RJ,  et al. (2009)
Altruistic learning.
Seymour B,  Yoshida W,  Dolan R,  et al. (2009)
The role of human orbitofrontal cortex in value comparison for incommensurable objects.
FitzGerald THB,  Seymour B,  Dolan RJ,  et al. (2009)
From threat to fear: the neural organization of defensive fear systems in humans.
Mobbs D,  Marchant JL,  Hassabis D,  Seymour B,  Tan G,  Gray M,  Petrovic P,  Dolan RJ,  Frith CD,  et al. (2009)
Choking on the money: reward-based performance decrements are associated with midbrain activity.
Mobbs D,  Hassabis D,  Seymour B,  Marchant JL,  Weiskopf N,  Dolan RJ,  Frith CD,  et al. (2009)
Encoding of marginal utility across time in the human brain.
Pine A,  Seymour B,  Roiser JP,  Bossaerts P,  Friston KJ,  Curran HV,  Dolan RJ,  et al. (2009)
A key role for similarity in vicarious reward.
Mobbs D,  Yu R,  Meyer M,  Passamonti L,  Seymour B,  Calder AJ,  Schweizer S,  Frith CD,  Dalgleish T,  et al. (2009)
A genetically mediated bias in decision making driven by failure of amygdala control.
Roiser JP,  de Martino B,  Tan GCY,  Kumaran D,  Seymour B,  Wood NW,  Dolan RJ,  et al. (2009)
Values and actions in aversion
Dayan P,  Seymour B,  et al. (2009)
Anchors, scales and the relative coding of value in the brain.
Seymour B,  McClure SM,  et al. (2008)
Striatal activity underlies novelty-based choice in humans.
Wittmann BC,  Daw ND,  Seymour B,  Dolan RJ,  et al. (2008)
Human pavlovian-instrumental transfer.
Talmi D,  Seymour B,  Dayan P,  Dolan RJ,  et al. (2008)
Dread and the disvalue of future pain.
Story GW,  Vlaev I,  Seymour B,  Winston JS,  Darzi A,  Dolan RJ,  et al. (2008)
Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and losses.
Petrovic P,  Pleger B,  Seymour B,  Klöppel S,  De Martino B,  Critchley H,  Dolan RJ,  et al. (2008)
Emotion, decision making, and the amygdala.
Seymour B,  Dolan R,  et al. (2007)
The neurobiology of punishment.
Seymour B,  Singer T,  Dolan R,  et al. (2007)
Differential encoding of losses and gains in the human striatum.
Seymour B,  Daw N,  Dayan P,  Singer T,  Dolan R,  et al. (2007)
When fear is near: threat imminence elicits prefrontal-periaqueductal gray shifts in humans.
Mobbs D,  Petrovic P,  Marchant JL,  Hassabis D,  Weiskopf N,  Seymour B,  Dolan RJ,  Frith CD,  et al. (2007)
The misbehavior of value and the discipline of the will.
Dayan P,  Niv Y,  Seymour B,  Daw ND,  et al. (2006)
Frames, biases, and rational decision-making in the human brain.
De Martino B,  Kumaran D,  Seymour B,  Dolan RJ,  et al. (2006)
Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans.
Pessiglione M,  Seymour B,  Flandin G,  Dolan RJ,  Frith CD,  et al. (2006)
Cortical substrates for exploratory decisions in humans.
Daw ND,  O'Doherty JP,  Dayan P,  Seymour B,  Dolan RJ,  et al. (2006)
Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network.
Kalisch R,  Korenfeld E,  Stephan KE,  Weiskopf N,  Seymour B,  Dolan RJ,  et al. (2006)
Empathic neural responses are modulated by the perceived fairness of others.
Singer T,  Seymour B,  O'Doherty JP,  Stephan KE,  Dolan RJ,  Frith CD,  et al. (2006)
Contingency awareness in human aversive conditioning involves the middle frontal gyrus.
Carter RM,  O'Doherty JP,  Seymour B,  Koch C,  Dolan RJ,  et al. (2006)
Anxiety reduction through detachment: subjective, physiological, and neural effects.
Kalisch R,  Wiech K,  Critchley HD,  Seymour B,  O'Doherty JP,  Oakley DA,  Allen P,  Dolan RJ,  et al. (2005)
Modulation of pain processing in hyperalgesia by cognitive demand.
Wiech K,  Seymour B,  Kalisch R,  Stephan KE,  Koltzenburg M,  Driver J,  Dolan RJ,  et al. (2005)
Opponent appetitive-aversive neural processes underlie predictive learning of pain relief.
Seymour B,  O'Doherty JP,  Koltzenburg M,  Wiech K,  Frackowiak R,  Friston K,  Dolan R,  et al. (2005)
Primary antibody deficiency and diagnostic delay.
Seymour B,  Miles J,  Haeney M,  et al. (2005)
Temporal difference models describe higher-order learning in humans.
Seymour B,  O'Doherty JP,  Dayan P,  Koltzenburg M,  Jones AK,  Dolan RJ,  Friston KJ,  Frackowiak RS,  et al. (2004)
Empathy for pain involves the affective but not sensory components of pain.
Singer T,  Seymour B,  O'Doherty J,  Kaube H,  Dolan RJ,  Frith CD,  et al. (2004)
Resting-state Amplitude of Low-frequency Fluctuation is a Potentially Useful Prognostic Functional Biomarker in Cervical Myelopathy.
Takenaka S,  Kan S,  Seymour B,  Makino T,  Sakai Y,  Kushioka J,  Tanaka H,  Watanabe Y,  Shibata M,  Yoshikawa H,  Kaito T,  et al. ()
Phasic and tonic pain serve distinct functions during adaptive behaviour
Tong S,  Denison T,  Hewitt D,  Lee SW,  Seymour B,  et al. ()
Tonic pain revalues associative memories of phasic pain
Hewitt D,  Tong S,  Schreiber S,  Seymour B,  et al. ()
Neural Associative Skill Memories for safer robotics and modelling human sensorimotor repertoires
Mahajan P,  Tang M,  Li TE,  Havoutis I,  Seymour B,  et al. ()
Balancing safety and efficiency in human decision-making
Mahajan P,  Tong S,  Lee SW,  Seymour B,  et al. ()