Raman spectroscopy, particularly Surface-Enhanced Raman Spectroscopy (SERS), is a powerful technology capable of capturing the unique molecular fingerprint of samples. The AI-aided analysis of subtle shifts in these molecular signatures provides a sensitive and versatile agnostic (i.e., non-dependent on any target molecule) biosensing platform. This platform can be used to detect pesticide contamination in food, monitor environmental pollutants, and assess chemical compositions in diverse settings. In healthcare, it is particularly valuable in diagnosing and monitoring complex conditions such as cancer, cardiovascular diseases, and neurological disorders, where multiple markers interact intricately, or reliable biomarkers remain unidentified. This innovative technology is developed by the Stevens Group in partnership with the BioInnovation Institute in Copenhagen.

The Functionalized Array for Surface-Enhanced Raman Spectroscopy (FASERS) is a platform made up of plasmonic surfaces, each coated with different molecular layers. These surfaces interact with complex biological samples to enhance the Raman signals of various molecules. By capturing a rich set of signals across the array, FASERS makes it easier to distinguish between closely related samples. Figure from https://doi.org/10.1038/s41467-019-13615-2.