Dr
Michael Gray
Senior Research Fellow in Clinical Therapeutic Ultrasound
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Tel: 01865 617677
Location: Institute of Biomedical Engineering, Marcela Botnar Wing, Oxford OX3 7LD
Site: Nuffield Orthopaedic Centre
Research Building: Botnar Research Centre

Dr. Michael Gray is a Senior Researcher in Clinical Therapeutic Ultrasound. He joined the BUBBL group in September 2015 as the lead engineer on a Phase-1 clinical trial of ultrasound-mediated targeted drug delivery for treatment of liver cancer.

Over the preceding 23 years, he was a research engineer and principal investigator at Georgia Tech, working in research areas including submarine sonar, cetacean soft tissue characterization, photoacoustics, fish hearing, and non-destructive structural evaluation.

Michael’s research focuses on three areas:

  1. Early phase clinical trials of ultrasound-mediated drug delivery for treatment of abdominal organ cancers
  2. Clinical translation of quantitative cavitation monitoring techniques for non-invasive treatment guidance
  3. Development of devices to enable targeted drug delivery

Ms Veerle Brans - Research Staff
Professor Robert Carlisle - Academic
Professor Robin Cleveland - Academic
Miss Abigail Collins - DPhil Student
Professor Constantin Coussios - Academic
Mr Darcy Dunn-Lawless - DPhil Student
Dr Brian Lyons - Research Staff
Dr Jeffrey Rubasingham - DPhil Student
Professor Eleanor Stride - Academic

Fuenteslópez, C.V., Gray, M.D., Bahcevanci, S., Martin, A., Smith, Cameron, Coussios, C., Cui, Z., Ye, H., & Patrulea, V. (2024). Mesenchymal stem cell cryopreservation with cavitation-mediated trehalose treatment. Commun Eng 3(129). DOI

Gray, M.D., Spiers, L., & Coussios, C. (2023). Sound speed and attenuation of human pancreas and pancreatic tumors and their influence on focused ultrasound thermal and mechanical therapies. Medical Physics 51: 809-825, DOI

Gray, M.D., Spiers, L., & Coussios, C. (2022). Effects of human tissue acoustic properties, abdominal wall shape, and respiratory motion on ultrasound-mediated hyperthermia for targeted drug delivery to pancreatic tumors. International Journal of Hyperthermia 39(1), 918-934, DOI

Gray, M.D., Elbes, D., Paverd, C., Lyka, E., Coviello, C., Cleveland, R., & Coussios, C. (2021). Dual array passive acoustic mapping for cavitation imaging with enhanced 2-D resolution. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 68(3), 647-663, DOI

Beguin, E., Gray, M.D., Logan, K.A., Nesbitt, H., Sheng, Y., Kamila, S., Barnsley, L.C., Bau, L., McHale, A.P., Callan, J.F., & Stride, E. (2020). Magnetic microbubble mediated chemo-sonodynamic therapy using a combined magnetic-acoustic device. Journal of Controlled Release 317, 23-33, DOI

Gray, M.D., Lyon, P.C., Mannaris, C., Folkes, L.K., Stratford, M., Campo, L., Chung, D.Y.F., Scott, S., Anderson, M., Goldin, R., Carlisle, R., Wu, F., Middleton, M.R., Gleeson, F.V., & Coussios, C.C. (2019). Focused Ultrasound Hyperthermia for Targeted Drug Release from Thermosensitive Liposomes: Results from a Phase I Trial. Radiology 291, 232-238, DOI

Gray, M.D. and Coussios, C.C. (2018). Broadband ultrasonic attenuation estimation and compensation with passive acoustic mapping. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 65(11), 1997-2011, DOI

Sengupta, A., Gray, M.D., Kelly, S.C., Holguin, S., Thadhani, N., & Prausnitz, M.R. (2017). Energy transfer mechanisms during molecular delivery to cells by laser-activated carbon nanoparticles.  Biophysical Journal 112, 1258-1269, DOI

Full Listing at Google Scholar

2024/25 MPLS Award for Outstanding Research Supervision

B17: Biomedical fluid mechanics

Biomedical ultrasound coursework module

Featured Publications by Dr Gray
> see all
Mesenchymal stem cell cryopreservation with cavitation-mediated trehalose treatment
Fuenteslópez CV,  Gray M,  Bahcevanci S,  Martin A,  Smith CAB,  Coussios C,  Cui Z,  Ye H,  Patrulea V,  et al. (2024)
Quantitative evaluation of anti-biofilm cavitation activity seeded from microbubbles or protein cavitation nuclei by passive acoustic mapping
Keller SB,  LuTheryn G,  Gray MD,  Lyons B,  Cleveland RO,  Stride E,  Coussios CC,  et al. (2024)
Combined drug delivery and treatment monitoring using a single high frequency ultrasound system
Yildiz YO,  Ruan J-L,  Gray M,  Bau L,  Mannaris C,  Kiltie AE,  Vojnovic B,  Stride E,  Browning RJ,  et al. (2024)
Challenges in classifying cavitation: correlating high-speed optical imaging and passive acoustic mapping of cavitation dynamics
Wu Q,  Gray M,  Smith C,  Bau L,  Cleveland R,  Coussios C-C,  Stride E,  et al. (2024)
Sound speed and attenuation of human pancreas and pancreatic tumors and their influence on focused ultrasound thermal and mechanical therapies
Gray MD,  Spiers L,  Coussios CC,  et al. (2023)
Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound
Spiers L,  Gray M,  Lyon P,  Sivakumar S,  Bekkali N,  Scott S,  Collins L,  Carlisle R,  Wu F,  Middleton M,  Coussios C-C,  et al. (2023)
Effects of human tissue acoustic properties, abdominal wall shape, and respiratory motion on ultrasound-mediated hyperthermia for targeted drug delivery to pancreatic tumors
Gray M,  Spiers L,  Coussios C,  et al. (2022)
Soundscapes as heard by invertebrates and fishes: Particle motion measurements on coral reefs.
Jones IT,  D Gray M,  Mooney TA,  et al. (2022)
PAX (Passive-Active Crossing) method for sub-millimeter coregistration of passive acoustic mapping and b-mode images
Gray MD,  Coussios CC,  et al. (2022)